Dr. Guéant-Rodriguez is a physician from the Universidad Nacional Autónoma de México, a cardiologist at the Hospital Español de Ciudad de México, and holds a Ph.D. in Nutrition from the University of Lorraine in France. She is currently a full professor of nutrition at the University of Lorraine and a physician at the University Hospital of Nancy.
She is in charge of three functional units, including a national reference laboratory for rare metabolic diseases designated by the Ministry of Health. She is responsible for neonatal screening of rare metabolic diseases in the Grand Est region of France. She is also accountable for neonatal screening of congenital homocystinuria in the northern half of France.
She serves as Deputy Head of the Division of Biochemistry, Molecular Biology, and Nutrition at the University Hospital of Nancy, France. She conducts clinical work on dyslipidemias and one-carbon metabolism disorders.
She has been working in one-carbon metabolism for more than 20 years, conducting studies in populations as well as experimental cellular and animal models. Along with her research group, she has demonstrated that deficiencies in methyl group donors affect fetal programming, leading to a higher risk of chronic diseases related to obesity.
Currently, she is studying the consequences of the conditional deletion of the Mtr gene (which encodes methionine synthase) in the heart and brain using behavioral, metabolomic, transcriptomic, proteomic, epigenomic, and systems biology approaches